- Slaughter at Acre – Fight against the prisoner at Acre
- Abandon All Hope – Break through the Gates of Hell
- Sentence the Judge – Defeat King Minos
- Lovers Torn Asunder – Defeat Marc Antony
- The Great Worm – Defeat Cerberus
- Like Father Like Son – Defeat Alighiero
- Gates of Dis – Enter the lower circles of The Inferno
- The Harrowing – Escape Heresy
- Precious – Find a Beatrice stone
- Footsteps of a Traitor – Find 10 pieces of silver
- Betrayed with a Kiss – Find 20 pieces of silver
- Relic Hunter – Find a relic
- Old Friend – Find and absolve Brunetto Latini
- Burning Eyes – Send Charon back into the abyss
- Warming Up – Perform a 50 hit combo
- Holy Warrior – Kill 30 Minions
- Demon Slayer – Kill 30 Demons
- Bad Nanny – Kill 20 Unbaptized Babies
- Indigestion – Kill 5 Gluttons
- Confessional – Kill 5 Heretics
- Countermeasures – Kill 20 enemies using a counter move
- Superstition – Kill 20 enemies using magic
- Give Me Strength – Open 20 Health fountains
- Sorcerer’s Apprentice – Open 20 Mana fountains
- Light in the Dark – Reach Holy Level 7
- Death’s Apprentice – Reach Unholy Level 7
- Brotherhood – Defeat Francesco
- Bitter Sweet – Save Beatrice
- Power of the Cross – Find all 3 Beatrice stones
- Well Done, Judas – Find all 30 pieces of silver
- Light Relics – Find all Holy relics
- Dark Relics – Find all Unholy relics
- Forbidden Love – Find and absolve both Francesca de Polenta and Paolo Malatesta
- The Damned – Punish or absolve all 27 shades of The Inferno
- The Guide – Collect all Virgil commentaries
- Soul Reaper – Collect 60,000 Souls
- Masterpiece – Perform a 200 hit combo
- Holy Man – Max out the Holy path
- Man of Evil – Max out the Unholy path
- Lucifer’s Match – Defeat the Emperor of the Woeful Realm
- Poetry in Motion – Perform a 666 hit combo
- Gates of Hell – Defeat all enemy waves in the Gates of Hell Arena
- Master of The Inferno – Unlock all other trophies