- Long Balls – Hit 25 Home Runs with your User Profile
- Even More Long Balls – Hit 50 Home Runs with your User Profile
- The Most Long Balls – Hit 100 Home Runs with your User Profile
- Feel the Heat – Strike out 25 batters with your User Profile
- That Guy’s Not Throwing it Nice – Strike out 50 batters with your User Profile
- There’s a Hole in My Bat – Strike out 100 batters with your User Profile
- Catch Me If You Can – Steal 25 bases with your User Profile
- Slippery When Wet – Steal 50 bases with your User Profile
- Good Things Always Happen in 3’s – Hit three Home Runs in a game
- It’s a Good Day to be a Hitter – Hit four Home Runs in a game
- Grab Some Pine – Strike out 12 batters in one game
- Pining Away – Strike out 15 batters in one game
- Unstoppable – Score 10 Runs in a game
- Has Anyone Seen the Fat Lady? – Score 15 Runs in a game
- Sticky Fingers – Steal 4 bases in one game
- Cat Burglar – Steal 6 bases in one game
- Flawless – Win a game without allowing any runs scored
- It’s Alive! – Create a Player
- Man-Crush – Hit a home run with Tim Lincecum
- Chicks Dig the Long Ball – Win the Classic Home Run Derby®
- I Could Have Been a Contender – Play a Ranked Game Online
- Two Turn Tables… – Create a 2K beats Playlist
- Absolute Power – Hit 40 Home Runs in a season with one player (play at least 20 games)
- May the Best Man… – Win 20 Games in a season with one pitcher (play at least 20 games)
- Centennial Man – Drive in 100 runs in a season with one player (play at least 20 games)
- Show Stopper – Save 40 games in a season with one player (play at least 20 games)
- Bicentennial Man – Strike out 200 batters in a season with one player (play at least 20 games)
- There Can be Only One – Win the World Series in Franchise mode (play at least 20 games)
- If You Build It… – Create a Card Team
- Spring Training – Try all 4 Practice Modes
- King of the Hill – Get to the top of the Best of the Best ladder in Home Run Derby® Mode
- Alone at the Top – Win the World Series in Postseason Mode (Play Final Game)
- SECRET Hard Knocks – Hit three batters in a row
- SECRET Expect the Unexpected – Drive in a run with a pitcher during a game
- Hurlers – Unlock all the pitcher cards in the game
- Crushers – Unlock all the batter cards in the game
- Teamwork – Unlock all nine cards for one team
- Spread the Wealth – Unlock one card on each of the 30 MLB teams
- A Man for All Seasons – Unlock 10 Classic Player Cards
- One Hundo – Unlock 100 cards
- Two Hundo – Unlock 200 cards
- All the Tea… – Unlock all 320 Cards
- Unhittable – Don’t give up any hits in a game
- SECRET Ya Can’t Get Fooled Again – Strike out a batter and throw out a runner on the same play
- SECRET That’s All Folks – Hit a home run to win a game
- SECRET This Old mMn Came Rolling Home – Steal home
- SECRET Vicious Cycle – Hit a home run, triple, double and single in one game with one player
- Team 2K – Beat a Team 2K member or someone that has unlocked this achievement in an online game
- SECRET Untouchable – Throw a No Hitter with one pitcher in a game
- Grand Poobah – Unlock all Trophies