- Wrecking Yard – Destroy 2,000 Vehicles
- Misconception – Destroy 25 infected water towers before they hatch
- Brain Trust – Complete all consume events
- Half-Truths – complete a mission without causing a single military alert
- Return Fire – Catch any object tossed by a hydra; and throw it back
- Gunning – Destroy 20 helicopters in a single helicopter flight
- Cleanup – kill 15 characters with a single whipfist attack
- The First Thread – unlock the web of intrigue
- Self-Deception – Discover what happened to alex mercer through the web of intrigue
- It’s Him! – Patsy 5 military personnel
- In Plain Sight – Evade 10 strike teams
- Infiltrator – Infiltrate 10 military bases disguised as a commander
- Threat Elevated – destroy 25 strike teams
- Repossession – seize 50 vehicles from enemy hands
- SME – Gain the ability to drive and fly all vehicles
- Surface-To-Air – Shoot down 50 helicopters while driving armor
- Evolutionary step – Use the upgrade menu to acquire an upgrade
- In The Web – consume 50 web targets
- Speed Bumps – Run over 500 characters in a single tank
- SECRET Crossing the T – You’ve completed the Hunter Boss Encounter.
- SECRET Errand Boy – You’ve completed the Specialist Boss Fight.
- SECRET Children Of Blacklight – You’ve completed the Supreme Hunter Boss Battle.
- SECRET On Instinct – You’ve completed the Mother Boss Battle.
- SECRET One Thousand Suns – You’ve completed the Supreme Hybrid Boss Battle.
- SECRET Hope – You’ve discovered the truth behind Hope, Idaho.
- SECRET Origin – You’ve discovered the history of Elizabeth Greene.
- Trail Of Corpses – Kill 53,596 infected
- Endless Hunger – Consume 200 characters to boost your health
- Streetwise – collect all landmark collectibles scattered across new york city
- Polymath – collect all hint collectibles scattered across new york city
- Mankind is your mask – complete 3 missions without causing a single military alert
- The butcher – Kill 50 characters in 5 seconds
- Unnatural Selection – Acquire all available upgrades
- The Cleaner – Destroy 10 military bases or infected hives in new york city
- Au – Achieve a rating of gold or better in all events
- Nice Guy – Complete the game while consuming 10 civilians or fewer
- Revenge Revisited – complete story mode on hard difficulty
- Web Of Knowledge – Acquire all nodes of the web of intrigue
- Hard To Kill – complete story mode in any difficulty without dying
- Pt – Achieve a platinum medal in all events
- Platinum Trophy – Platinum Trophy